Сообщение
Freki » Пн ноя 07, 2005 5:50 pm
Так, скажу и я.
1. При использовании нандролона нельзя использовать финастерид(дутастерид) т.к. этим предотвращается конвертация нандролона в дигидронандролон, который, как не странно, менее андрогенен.
1.1. Нандролон, помимо прогестагенной активности, ароматизируется, но не в эстрадиол, а в эстрон.
Androgen and 19-norandrogen aromatization by equine and human placental microsomes.
Dintinger T, Gaillard JL, Moslemi S, Zwain I, Silberzahn P.
Laboratoire de Biochimie, URA CNRS 59, Universite, Caen, France.
The ability of equine and human placental microsomes to aromatize testosterone and 19-nortestosterone was studied. When 3 microM [1 beta,2 beta-3H]testosterone was used as substrate, the specific activity of equine placental microsomal aromatase was 2.5 times higher than that of the human microsomal enzyme. Although 19-nortestosterone was aromatized 67 times more rapidly by equine than by human aromatase, we found that equine aromatase exhibited a markedly weaker affinity for this substrate than did the human enzyme. Competitive inhibition of testosterone aromatization by 19-nortestosterone occurred with both equine and human aromatases. While having no effect on mare placental microsomes, Na+ and K+ (500 mM) stimulated testosterone aromatization by human placental microsomes by 73 and 52% respectively. If indeed a single enzyme is responsible for the aromatization of testosterone and 19-nortestosterone, which seems to be the case in both equine and human placental aromatase, our results show that differences in the structure of the active sites exist between equine and human aromatases.
2. Трен ни во что не конвертируется.
3. Следовательно, комбинация Тесто+Нандролон+Финастерид отпадает, зато безопасно Тесто+Трен+Финастерид, очень популярно у лысеющих буржуйских качков.